2-hydrazinobenzothiazole Preparation or source: derived from tar base. It can also be prepared by acetaldehyde method (reaction of acetaldehyde, formaldehyde and ammonia), acetylene method (reaction of acetylene and ammonia), ethylene method (reaction of ethylene with ammonia) and acrylonitrile method (reaction of acrylonitrile with excess acetone).
Chemical properties: A colorless oily liquid with a strong unpleasant odor of pyridine. Soluble in acetone and ether. It is miscible with water and ethanol. Use as a solvent and chromatographic analysis reagent, but also for industrial use in organic synthesis, 2-hydrazinobenzothiazole is an intermediate of the plant growth regulator pyridinol.
Application: Used for preparation of 2-vinylpyridine, nitrogen-based synergist (N-Serve), long-acting sulfanilamide, antisilicic, livestock deworming, poultry medicine, organophosphorus antidote, local anesthetics, laxatives, film sensitizer additives, dye intermediates and rubber accelerators, etc. Used as raw materials for the synthesis of medicine, dyes and resins, it can be used to produce chemical fertilizer synergists, herbicides, animal repellents, rubber accelerators, dye intermediates and other uses for the synthesis of drugs, dyes, rubber and other chemicals, and also used as solvents and experimental reagents to test cobalt, cyanate and iron. Organic synthesis.
Production method: Pyridine and methylpyridine were previously recovered from coal coking byproducts, which are distributed in coke oven gas, crude benzene and tar. Generally, the boiling point of pyridine hydrates transferred from gas to ammonium sulphate mother liquor is very low, ranging from 95-97℃. The recovered crude light pyridine base contains about 15%, 2-hydrazinobenzothiazole, which can be cut to 2-hydrazinobenzothiazole by further distillation. With the expansion of the use of pyridine and methylpyridine, the synthesis of pyridine and methylpyridine has been developed. At present, about 95% of pyridine and pyridine compounds abroad are produced by synthetic methods. The main synthesis methods are acetaldehyde, acetylene, acrylonitrile and so on. Acetaldehyde process acetaldehyde, formaldehyde and ammonia reaction, the main products are 2-hydrazinobenzothiazole, 3-methylpyridine and 4-methylpyridine. Acetylene process acetylene and ammonia reaction, the main products are 2-hydrazinobenzothiazole and 4-methylpyridine. The main products are 2-hydrazinobenzothiazole and 2- methyl -5- ethyl pyridine. Acrylonitrile process reaction of acrylonitrile with excess acetone, the main product is 2-hydrazinobenzothiazole. In addition, the reaction of acrolein and ammonia mainly produces 3-methylpyridine. The preparation method is acetaldehyde as raw material, and ammonia gas in the presence of catalyst gas reaction temperature in 350 ~ 500℃, the product, at the same time there are 4-methylpyridine byproduct.
2-hydrazinobenzothiazole
Class: Flammable liquid.
Toxicity classification: Toxic acute toxicity orally - rat LD50:790 mg/kg; Orally - Mouse LD50:674 mg/kg.
Irritation Data: Skin - Rabbit 10mg /24 h mild; Eye - Rabbit 0.75mg Heavy.
Hazardous characteristics of explosive material: Explosive when mixed with air.
Flammability risk characteristics: in case of open fire, high temperature, oxidizer is more flammable; Heat produces toxic nitrogen oxide gas.
Storage and transportation characteristics: warehouse ventilation low temperature dry; Store separately from oxidants and acids.
Extinguishing agent: dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent.
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